The HudsonAlpha Institute for Biotechnology has a four-fold mission of conducting genomics-based research to improve human health and well being; implementing genomic medicine, sparking economic development; and providing educational outreach to nurture the next generation of biotech researchers and entrepreneurs, as well as to create a biotech literate public. HudsonAlpha unites these four endeavors into a single enterprise. Since the Institute’s 2008 opening, HudsonAlpha has generated major discoveries that impact disease diagnosis and treatment, created intellectual property, created a clinical genomic medicine program, fostered biotechnology companies, and expanded the number of biosciences-literate people, many of whom will be the future workforce.